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1.
J Healthc Qual Res ; 39(1): 41-49, 2024.
Artigo em Espanhol | MEDLINE | ID: mdl-38123402

RESUMO

BACKGROUND AND AIM: Safety culture (SC) is a fundamental tool for minimizing adverse events and improving safety and quality of care. Our objective, therefore was to analyze the evolution of the SC of healthcare professionals in a pediatric emergency department (PED) after the implementation of a risk management system for patient safety based on the UNE:EN:ISO 179003 Standard and the execution of new safe practices for Joint Commission International accreditation. At the same time describe the current strengths and weaknesses. METHODS: Quasi-experimental, single-center study. All PED professionals participated in the study. An initial measurement of SC was performed through the Hospital Survey on Patient Safety Culture (HSOPS) questionnaire of the Agency for Healthcare Research and Quality adapted to Spanish in 2014. Pro-patient safety strategies were implemented between 2015 and 2022. A subsequent measurement was performed in 2022. RESULTS: The response rate in 2014 was 55% and 78% in 2022. On both occasions the group with the highest participation was nurses with 35.1% and 34.8%, respectively. Five dimensions improved after the interventions: frequency of adverse events (25.2%, p<0.001), organizational learning (25%, p<0.001), feedback and communication about errors (22.3%, p<0.001), non-punitive response to errors (6.5%, p = 0.176), and management support (4%, p = 0.333). CONCLUSIONS: The actions carried out had a positive influence on organizational learning and the frequency of adverse events reported and communication within the team. In contrast, the perception of SC did not increase.


Assuntos
Gestão de Riscos , Gestão da Segurança , Criança , Humanos , Atitude do Pessoal de Saúde , Serviço Hospitalar de Emergência , Percepção
2.
Neurologia (Engl Ed) ; 37(5): 317-324, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35672118

RESUMO

OBJECTIVE: We aimed to analyse the prevalence, characteristics, and management of simple and complex febrile seizures. The secondary objective was to compare the risk of underlying organic lesion and epilepsy in both types of seizures, with a particular focus on the different subtypes defining a complex febrile seizure. MATERIAL AND METHODS: We performed a retrospective cohort study including patients aged 0--16 years who were treated for febrile seizures in the paediatric emergency department of a tertiary hospital over a period of 5 years. Epidemiological and clinical variables were collected. Patients were followed up for at least 2 years to confirm the final diagnosis. RESULTS: We identified 654 patients with febrile seizures, with a prevalence of 0.20% (95% CI, 0.18-0.22); 537 (82%) had simple febrile seizures and 117 (18%) had complex febrile seizures. The clinical and epidemiological characteristics of both types were similar. Significantly more complementary tests were requested for complex febrile seizures: blood tests (71.8% vs 24.2% for simple febrile seizures), urine analysis (10.3% vs 2.4%), lumbar puncture (14.5% vs 1.5%), and CT (7.7% vs 0%). Similarly, admission was indicated more frequently (41.0% vs 6.1%). Underlying organic lesions (central nervous system infection, metabolic disease, tumour/intracranial space-occupying lesion, intoxication) were diagnosed in only 11 patients, 5 of whom had complex forms (4.3%; 95% CI, 0.6-7.9). Risk factors for developing epilepsy, identified in the multivariate analysis, were complex forms with recurrent seizures in a single attack (odds ratio [OR]: 4.94; 95% CI, 1.29-18.95), history of seizures (OR: 17.97; 95% CI, 2.26--143.10), and seizures presenting at atypical ages (OR: 11.69; 95% CI, 1.99-68.61). CONCLUSIONS: The systematic indication of complementary tests or hospital admission of patients with complex febrile seizures is unnecessary. The risk of epilepsy in patients with complex forms gives rise to the need for follow-up in paediatric neurology departments.


Assuntos
Epilepsia , Convulsões Febris , Criança , Serviço Hospitalar de Emergência , Epilepsia/complicações , Epilepsia/diagnóstico , Epilepsia/epidemiologia , Humanos , Estudos Retrospectivos , Convulsões Febris/diagnóstico , Convulsões Febris/epidemiologia , Convulsões Febris/etiologia , Punção Espinal/efeitos adversos
3.
Neurología (Barc., Ed. impr.) ; 37(5): 317-324, Jun. 2022. ilus, tab
Artigo em Inglês, Espanhol | IBECS | ID: ibc-205981

RESUMO

Objetivo: Analizar la prevalencia, características y manejo de las convulsiones febriles simples y complejas. Secundariamente, comparar el riesgo de lesión orgánica subyacente y epilepsia entre ambos tipos de crisis y particularmente de cada subtipo que define una convulsión febril compleja. Material y método: Estudio de cohortes retrospectivo que incluye pacientes de 0-16 años que consultan por convulsión febril en urgencias pediátricas de un hospital terciario durante 5 años. Se recogen variables epidemiológicas y clínicas. Se realiza un seguimiento posterior mínimo de 2 años para confirmar el diagnóstico final. Resultados: Se incluyeron 654 convulsiones febriles, con una prevalencia del 0,20% (IC 95%: 0,18-0,22%); 537 fueron simples (82%) y 117 complejas (18%). Las características clínico-epidemiológicas de ambos tipos fueron similares. En las formas complejas se solicitaron significativamente más pruebas complementarias en forma de analíticas (71,8% vs. 24,2%), tóxicos (10,3% vs. 2,4%), punción lumbar (14,5% vs. 1,5%) y TAC (7,7% vs. 0%). Igualmente se indicó ingreso con mayor frecuencia (41,0% vs. 6,1%). No se diagnosticó ninguna lesión orgánica subyacente (infección del sistema nervioso central, enfermedad metabólica, tumor/lesión intracraneal ocupante de espacio, intoxicación) excepto 11 casos de epilepsia, 5 de ellas en las formas complejas (4,3%; IC 95%: 0,6-7,9%). En el análisis multivariable presentaron mayor riesgo de desarrollar epilepsia las formas complejas por ser recurrentes en el mismo proceso febril (odds ratio [OR]: 4,94; IC 95%: 1,29-18,95), aquellos con antecedentes de crisis previas (OR: 17,97; IC 95%: 2,26-143,10) y las manifestadas a edades atípicas (OR: 11,69; IC 95%: 1,99-68,61). Conclusiones: No está justificada la indicación sistemática de pruebas complementarias o ingreso en las convulsiones febriles complejas. El riesgo de epilepsia en las formas complejas hace necesario el seguimiento en neuropediatría. (AU)


Objective: We aimed to analyse the prevalence, characteristics, and management of simple and complex febrile seizures. The secondary objective was to compare the risk of underlying organic lesion and epilepsy in both types of seizures, with a particular focus on the different subtypes defining a complex febrile seizure. Material and methods: We performed a retrospective cohort study including patients aged 0-16 years who were treated for febrile seizures in the paediatric emergency department of a tertiary hospital over a period of 5 years. Epidemiological and clinical variables were collected. Patients were followed up for at least 2 years to confirm the final diagnosis. Results: We identified 654 patients with febrile seizures, with a prevalence of 0.20% (95% CI, 0.18-0.22); 537 (82%) had simple febrile seizures and 117 (18%) had complex febrile seizures. The clinical and epidemiological characteristics of both types were similar. Significantly more complementary tests were requested for complex febrile seizures: blood tests (71.8% vs 24.2% for simple febrile seizures), urine analysis (10.3% vs 2.4%), lumbar puncture (14.5% vs 1.5%), and CT (7.7% vs 0%). Similarly, admission was indicated more frequently (41.0% vs 6.1%). Underlying organic lesions (central nervous system infection, metabolic disease, tumour/intracranial space-occupying lesion, intoxication) were diagnosed in only 11 patients, 5 of whom had complex forms (4.3%; 95% CI, 0.6-7.9). Risk factors for developing epilepsy, identified in the multivariate analysis, were complex forms with recurrent seizures in a single attack (odds ratio [OR]: 4.94; 95% CI, 1.29-18.95), history of seizures (OR: 17.97; 95% CI, 2.26-143.10), and seizures presenting at atypical ages (OR: 11.69; 95% CI, 1.99-68.61). Conclusions: The systematic indication of complementary tests or hospital admission of patients with complex febrile seizures is unnecessary. [...] (AU)


Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Epilepsia/complicações , Epilepsia/diagnóstico , Epilepsia/epidemiologia , Convulsões Febris/diagnóstico , Convulsões Febris/epidemiologia , Convulsões Febris/etiologia , Serviços Médicos de Emergência , Hospitais , Estudos Retrospectivos , Punção Espinal/efeitos adversos , Pediatria
4.
Neurologia (Engl Ed) ; 2019 Jul 17.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31326213

RESUMO

OBJECTIVE: We aimed to analyse the prevalence, characteristics, and management of simple and complex febrile seizures. The secondary objective was to compare the risk of underlying organic lesion and epilepsy in both types of seizures, with a particular focus on the different subtypes defining a complex febrile seizure. MATERIAL AND METHODS: We performed a retrospective cohort study including patients aged 0-16 years who were treated for febrile seizures in the paediatric emergency department of a tertiary hospital over a period of 5 years. Epidemiological and clinical variables were collected. Patients were followed up for at least 2 years to confirm the final diagnosis. RESULTS: We identified 654 patients with febrile seizures, with a prevalence of 0.20% (95% CI, 0.18-0.22); 537 (82%) had simple febrile seizures and 117 (18%) had complex febrile seizures. The clinical and epidemiological characteristics of both types were similar. Significantly more complementary tests were requested for complex febrile seizures: blood tests (71.8% vs 24.2% for simple febrile seizures), urine analysis (10.3% vs 2.4%), lumbar puncture (14.5% vs 1.5%), and CT (7.7% vs 0%). Similarly, admission was indicated more frequently (41.0% vs 6.1%). Underlying organic lesions (central nervous system infection, metabolic disease, tumour/intracranial space-occupying lesion, intoxication) were diagnosed in only 11 patients, 5 of whom had complex forms (4.3%; 95% CI, 0.6-7.9). Risk factors for developing epilepsy, identified in the multivariate analysis, were complex forms with recurrent seizures in a single attack (odds ratio [OR]: 4.94; 95% CI, 1.29-18.95), history of seizures (OR: 17.97; 95% CI, 2.26-143.10), and seizures presenting at atypical ages (OR: 11.69; 95% CI, 1.99-68.61). CONCLUSIONS: The systematic indication of complementary tests or hospital admission of patients with complex febrile seizures is unnecessary. The risk of epilepsy in patients with complex forms gives rise to the need for follow-up in paediatric neurology departments.

7.
Acta pediatr. esp ; 75(11/12): e195-e199, nov.-dic. 2017. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-170221

RESUMO

Introducción: La presencia de un tiempo de cefalina (APTT) alargado en niños con fiebre y petequias es un hallazgo descrito en la bibliografía. La causa de esta alteración se desconoce, pero se postula que puede deberse a la formación de anticuerpos antifosfolípidos (Ac AFL). El objetivo de este estudio es determinar si el alargamiento del APTT se asocia con la formación Ac AFL. Pacientes y métodos: Estudio observacional, prospectivo, de casos y controles, realizado en niños que consultaron por fiebre y petequias en el servicio de urgencias de un hospital de tercer nivel durante un periodo de 13 meses. Se recogieron variables epidemiológicas, clínicas y analíticas. Se describieron las características de los grupos con APTT alargado y normal, y se comparó la asociación entre las concentraciones de los diferentes anticuerpos y el APTT. Resultados: Se incluyeron 36 pacientes, 12 casos y 24 controles. No se encontraron diferencias significativas respecto a la positividad de Ac AFL entre los casos y los controles (odds ratio [OR]= 1,67; intervalo de confianza [IC] del 95%: 0,31-9,04). No se observó ninguna asociación entre los diferentes tipos de anticuerpos y el APTT, cuyos coeficientes de regresión fueron de 0,04 seg (IC del 95%: -0,31 a 0,40) para anticardiolipina IgG, de 1,11 seg (IC del 95%: -1,24 a 3,46) para la IgM, y de -0,02 seg (IC del 95%: -0,35 a 0,31) y 0,64 seg (IC del 95%: -1,40 a 2,68) para antibeta 2 GPI, IgG e IgM, respectivamente. Conclusión: Ante los resultados de nuestro estudio, no podemos concluir que el alargamiento de APTT se relacione con la presencia de Ac AFL (AU)


Introduction: The presence of a longer time of cephalin (APTT) extended in children who come to emergency department with fever and petechiae is a result previously described in the literature. The cause of this alteration in coagulation is unknown, it is presumed that may be due to the formation of antiphospholipids antibodies. The aim of this study is to determine if the length of APTT is associated to the formation of antiphospholipids antibodies. Patients and methods: Observational, prospective case-control study in children who consulted for fever and petechiae in the emergency department of a tertiary hospital over a 13-month period epidemiological; clinical and laboratory variables were collected. The characteristics of groups with elongated and normal APTT were described and the association between concentrations of different antibodies and APTT were compared. Results: 36 patients, 12 cases and 24 controls, were included. No significant differences were found regarding the positivity of antiphospholipid antibodies between cases and controls (OR= 1.67; 95%CI: 0.31 to 9.04). No association was observed between the different types of antibodies and APTT, resulting regression coefficients in 0.04 s (95%CI: -0.31 to 0.40) for cardiolipin IgG, 1.11 s (95%CI: -1.24 to 3.46) for IgM and -0.02 s (95%CI: -0.35 to 0.31) and 0,64 s (95%CI: -1.40 to 2.68) for antibeta 2 GPI, IgG and IgM, respectively. Conclusion: Given the results of our study we can not conclude that the elongation of APTT is related with the presence of antiphospholipids antibodies (AU)


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Febre/etiologia , Púrpura/etiologia , Síndrome Antifosfolipídica/epidemiologia , Tempo de Tromboplastina Parcial/estatística & dados numéricos , Anticorpos Antifosfolipídeos/isolamento & purificação , Biomarcadores/análise , Anticorpos Anticardiolipina/isolamento & purificação , Estudos Prospectivos , Estudos de Casos e Controles
8.
Arch Soc Esp Oftalmol ; 83(3): 177-82, 2008 Mar.
Artigo em Espanhol | MEDLINE | ID: mdl-18311677

RESUMO

OBJECTIVE: Helicobacter pylori (HP) gastric infection has been implicated as an important factor in occlusive arterial pathology. Nowadays, it is suspected that central serous chorioretinopathy (CSC) is due to a multifocal vascular occlusive disease of the choriocapillaris. The aim of this study was to determine the relation between gastric HP infection and CSC. MATERIALS AND METHODS: We evaluated a group of 16 patients with CSC and 20 controls. HP infection was assessed by the 13C-urea breath test (UBT). Clinical CSC diagnosis was confirmed by fundus biomicroscopy and fluorescein angiography. RESULTS: Out of 16 patients with CSC, 11 (68.75%) were males and 5 (31.25%) females, with a mean age of 46.3 years. HP infection was positive in 11 patients (68.75%) and negative in 5 (31.25%). Men were HP-positive (HP+) in 72.7% of cases, compared to women who were HP+ in 60% of cases. The difference in prevalence of HP between the CSC-group (68.75%) and the control-group (30%) was found to be statistically significant (p< 0.05). HP+ patients had more gastric pain than HP negative (HP-) patients (72.73% vs 20%). CONCLUSIONS: These results indicate a possible statistical association between Helicobacter pylori gastric infection and CSC. HP should thus be considered a risk factor in CSC patients.


Assuntos
Doenças da Coroide/microbiologia , Infecções por Helicobacter/complicações , Helicobacter pylori , Doenças Retinianas/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
9.
Arch. Soc. Esp. Oftalmol ; 83(3): 177-182, mar. 2008. tab
Artigo em Es | IBECS | ID: ibc-62877

RESUMO

Objetivo: Determinar los niveles de eritropoyetina (Epo) en el vítreo de pacientes con retinopatía diabética proliferante (RDP). Material y método: Mediante vitrectomía vía pars plana, se recogieron muestras no diluidas de vítreo de 44 pacientes sin antecedentes de cirugía vítrea o intraocular previa, que fueron divididos en dos grupos: A (n=24) pacientes con RDP y B (n=20) pacientes con desprendimiento de retina, membrana premacular y agujero macular. La concentración de Epo se determinó mediante radioinmunoensayo. Resultados: La concentración vítrea de Epo en el grupo A fue 512 mU/mL (rango 120-880) y en el grupo B fue 25,1 mU/ml (rango 5,2-201) (p< 0,001). Conclusiones: Estos resultados demuestran que la concentración vítrea de Epo está más elevada en los pacientes con RDP en comparación con el grupo control


Objective: To measure erythropoietin (Epo) levels in the vitreous body from patients with proliferative diabetic retinopathy (PDR). Patients and methods: Undiluted vitreous samples were obtained from 44 patients who had not undergone prior vitreous or intraocular surgery. Patients were divided into two groups: A (n= 24) patients with PDR and B (n= 20) patients with retinal detachment, preretinal macular membranes and macular holes. Epo was determined using radioimmunoassay. Results: Epo vitreous concentration in group A was 512 mU/mL (range 120-880) and in group B was 25.1 mU/mL (range 5.2-201) (p< 0.001). Conclusions: These results show that the concentration of Epo in the vitreous body was significantly higher in patients with PDR than in the control group (Arch Soc Esp Oftalmol 2008; 83: 169-172)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Infecções Oculares Bacterianas/microbiologia , Doenças da Coroide/microbiologia , Doenças Retinianas/microbiologia , Infecções por Helicobacter/microbiologia , Helicobacter pylori/isolamento & purificação , Estudos de Casos e Controles , Angiofluoresceinografia , Estudos Retrospectivos , Fatores de Risco , Ensaio de Imunoadsorção Enzimática
10.
Arch Soc Esp Oftalmol ; 83(2): 85-8, 2008 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-18260018

RESUMO

OBJECTIVE: To study the prevalence of microalbuminuria and its association with more severe diabetic retinopathy in a group of insulin-dependent diabetic patients. MATERIALS AND METHODS: During the period of January 1998 to December 2005 we examined 360 insulin-dependent diabetic patients with at least five years of evolution. We evaluated the presence of microalbuminuria by immunoanalysis. Patients were evaluated by direct and indirect ophthalmoscopy and classified as non-retinopathy, non-proliferative, severe non-proliferative/proliferative, or macular edema. RESULTS: In this study, 24.1% of patients had microalbuminuria. Most of the patients with microalbuminuria and macroalbuminuria were male and had a longer history of diabetes. Microalbuminuria was associated with more severe diabetic retinopathy. CONCLUSIONS: All patients with insulin-dependent diabetes of at least five years' evolution should undergo an evaluation of renal function including tests for microalbuminuria. In the presence of microalbuminuria an ophthalmologic follow-up may be particularly important.


Assuntos
Albuminúria/complicações , Albuminúria/epidemiologia , Retinopatia Diabética/complicações , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência
11.
Arch. Soc. Esp. Oftalmol ; 83(2): 85-88, feb. 2008. tab
Artigo em Es | IBECS | ID: ibc-059029

RESUMO

Objetivo: Estudiar la prevalencia de microalbuminuria y su asociación con las formas más severas de retinopatía diabética en una población de diabéticos insulinodependientes. Material y método: Se estudiaron 360 pacientes con diabetes insulinodependiente con al menos cinco años de evolución en un periodo comprendido entre enero de 1998 y diciembre de 2005. Se evaluó la presencia de microalbuminuria por inmunoanálisis. Los pacientes fueron estudiados con oftalmoscopía directa e indirecta y clasificados como no retinopatía, retinopatía no proliferante, retinopatía no proliferante severa / proliferante y edema macular. Resultados: En este estudio el 24,1% de los pacientes tenían microalbuminuria. La mayoría de los pacientes con microalbuminuria y macroalbuminuria eran varones con mayor tiempo de evolución de la diabetes. La microalbuminuria se asoció con las formas más severas de retinopatía diabética. Conclusiones: Todos los pacientes diabéticos insulinodependiente con al menos cinco años de evolución deberían ser evaluados en su función renal incluida la microalbuminuria y los pacientes con microalbuminuria deberían ser revisados más frecuentemente


Objective: To study the prevalence of microalbuminuria and its association with more severe diabetic retinopathy in a group of insulin-dependent diabetic patients. Materials and methods: During the period of January 1998 to December 2005 we examined 360 insulin-dependent diabetic patients with at least five years of evolution. We evaluated the presence of microalbuminuria by immunoanalysis. Patients were evaluated by direct and indirect ophthalmoscopy and classified as non-retinopathy, non-proliferative, severe non-proliferative/proliferative, or macular edema. Results: In this study, 24.1% of patients had microalbuminuria. Most of the patients with microalbuminuria and macroalbuminuria were male and had a longer history of diabetes. Microalbuminuria was associated with more severe diabetic retinopathy. Conclusions: All patients with insulin-dependent diabetes of at least five years’ evolution should undergo an evaluation of renal function including tests for microalbuminuria. In the presence of microalbuminuria an ophthalmologic follow-up may be particularly important


Assuntos
Masculino , Feminino , Humanos , Albuminúria/epidemiologia , Retinopatia Diabética/epidemiologia , Albuminúria/complicações , Retinopatia Diabética/classificação , Espanha/epidemiologia , Comorbidade , Cegueira/epidemiologia , Hipertensão/epidemiologia , Fatores de Risco , Estudos Epidemiológicos , Diabetes Mellitus Tipo 2/complicações
12.
Arch. Soc. Esp. Oftalmol ; 82(12): 753-756, dic. 2007. tab
Artigo em Es | IBECS | ID: ibc-058302

RESUMO

Objetivo: La retinopatía diabética proliferante (RDP) se caracteriza por pérdida de la visión en la población joven. Está bien establecido que el antígeno leucocitario humano (HLA)-A24 es un factor de riesgo para la pérdida total de las células‚ del páncreas. Nuestro objetivo es estudiar la asociación del HLA-A24 con la RDP. Material y método: Se estudió un grupo de pacientes con RDP (n= 95) y un grupo control (n= 60). A todos se les determinó el HLA-A24 mediante técnicas hibridación molecular. Resultados: El grupo control mostró menos frecuencia de HLA-A24 que el grupo con RDP (p= 0,043). El HLA-A24 se asoció a retinopatía diabética proliferante (OR = 5,4; 95% CI= 3,2-7,6; p< 0,001). Conclusiones: El HLA-A24 no es un factor de protección para la retinopatía diabética proliferante, es un factor de riesgo para desarrollarla


Objective: Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)- A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR. Materials and methods: We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques. Results: The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001). Conclusions: HLA-A24 is not a protective factor for PDR, but is a risk factor of its development


Assuntos
Masculino , Feminino , Pessoa de Meia-Idade , Humanos , Retinopatia Diabética/complicações , Retinopatia Diabética/diagnóstico , Retinopatia Diabética/terapia , Fatores de Risco , Antígenos HLA/efeitos adversos , Teste de Histocompatibilidade/efeitos adversos , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/diagnóstico , Seleção de Pacientes , Oftalmopatias/complicações , Oftalmopatias/diagnóstico
13.
Arch Soc Esp Oftalmol ; 82(12): 753-6, 2007 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-18040918

RESUMO

OBJECTIVE: Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)-A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR. MATERIALS AND METHODS: We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques. RESULTS: The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001). CONCLUSIONS: HLA-A24 is not a protective factor for PDR, but is a risk factor of its development.


Assuntos
Retinopatia Diabética/sangue , Antígenos HLA-A/sangue , Idoso , Retinopatia Diabética/etiologia , Feminino , Antígeno HLA-A24 , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
14.
Arch Soc Esp Oftalmol ; 82(5): 299-301, 2007 May.
Artigo em Espanhol | MEDLINE | ID: mdl-17516267

RESUMO

CASE REPORT: We describe a case of a 74-year-old woman who experienced visual hallucinations after ciprofloxacin administration, when she was also taking theophylline, which resolved on cessation of the ciprofloxacin. DISCUSSION: Although uncommon, all ophthalmologists should be aware of this potential problem and be familiar with the adverse visual effects which may occur in patients simultaneously administered quinolones and theophylline.


Assuntos
Anti-Infecciosos/efeitos adversos , Ciprofloxacina/efeitos adversos , Alucinações/induzido quimicamente , Idoso , Feminino , Humanos , Embolia Pulmonar/tratamento farmacológico
15.
Arch. Soc. Esp. Oftalmol ; 82(5): 299-300, mayo 2007. ilus
Artigo em Es | IBECS | ID: ibc-054976

RESUMO

Caso clínico: Se describe el caso de una mujer de 74 años que tuvo alucinaciones visuales después de la administración de ciprofloxacino cuando estaba tomando una teofilina, resolviéndose el cuadro alucinatorio cuando se suspendió el ciprofloxacino. Discusión: Aunque es poco frecuente, todos los oftalmólogos deberían estar alerta y conocer los posibles efectos adversos visuales en pacientes con tratamiento simultáneo de quinolonas y teofilinas


Case report: We describe a case of a 74-year-old woman who experienced visual hallucinations after ciprofloxacin administration, when she was also taking theophylline, which resolved on cessation of the ciprofloxacin. Discussion: Although uncommon, all ophthalmologists should be aware of this potential problem and be familiar with the adverse visual effects which may occur in patients simultaneously administered quinolones and theophylline


Assuntos
Feminino , Pessoa de Meia-Idade , Humanos , Ciprofloxacina/efeitos adversos , Ciprofloxacina/uso terapêutico , Alucinações/complicações , Alucinações/diagnóstico , Teofilina/uso terapêutico , Quinolonas/uso terapêutico , Tomografia Computadorizada de Emissão/métodos , Peptídeos Catiônicos Antimicrobianos/efeitos adversos , Peptídeos Catiônicos Antimicrobianos/uso terapêutico , Quinolonas/administração & dosagem , Quinolonas/efeitos adversos
16.
Arch Soc Esp Oftalmol ; 82(1): 43-5, 2007 Jan.
Artigo em Espanhol | MEDLINE | ID: mdl-17262236

RESUMO

CASE REPORT: We report a 34-year-old woman with biopsy proven type II mesangiocapillary glomerulonephritis (MCG II) who had an ophthalmic fundal appearance similar to that seen in patients with age-related macular degeneration (ARMD). DISCUSSION: All patients with MCG II should be reviewed regularly by an ophthalmologist to assess and treat any retinal complications.


Assuntos
Glomerulonefrite Membranoproliferativa/complicações , Degeneração Macular/etiologia , Adulto , Feminino , Humanos
17.
Arch. Soc. Esp. Oftalmol ; 82(1): 43-46, ene. 2007. ilus
Artigo em Es | IBECS | ID: ibc-052354

RESUMO

Caso clínico: Se describe una mujer de 34 años diagnosticada por biopsia de una glomerulonefritis mesangiocapilar tipo II (GMC II) y con un fondo de ojo similar al que se puede describir en un paciente con degeneración macular asociada a la edad (DMAE). Discusión: Todos los pacientes con GMC II deben ser evaluados periódicamente por un oftalmólogo para controlar las complicaciones retinianas


Case report: We report a 34-year-old woman with biopsy proven type II mesangiocapillary glomerulonephritis (MCG II) who had an ophthalmic fundal appearance similar to that seen in patients with agerelated macular degeneration (ARMD). Discussion: All patients with MCG II should be reviewed regularly by an ophthalmologist to assess and treat any retinal complications


Assuntos
Feminino , Adulto , Humanos , Glomerulonefrite Membranoproliferativa/complicações , Degeneração Macular/complicações , Fundo de Olho , Angiografia
18.
Arch. Soc. Esp. Oftalmol ; 81(12): 717-719, dic. 2006. ilus
Artigo em Es | IBECS | ID: ibc-055591

RESUMO

Caso clínico: Paciente de 58 años con una agudeza visual de 0,1 en el ojo izquierdo asociada a un desprendimiento seroso de la mácula como única manifestación ocular de la enfermedad del arañazo del gato. El diagnóstico se realizó con estudios serológicos y por la evolución clínica. Discusión: Aunque es poco frecuente, la enfermedad del arañazo del gato debería considerarse en el diagnóstico diferencial del desprendimiento seroso de mácula


Case report: A 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. This diagnosis was made by serum antibody titers and the clinical course. Discussion: Although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina


Assuntos
Animais , Feminino , Pessoa de Meia-Idade , Gatos , Humanos , Descolamento Retiniano , Doença da Arranhadura de Gato/complicações , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Bartonella henselae/imunologia , Eritema Nodoso/etiologia , Imunoglobulina M/sangue , Imunoglobulina M/imunologia , Lacerações/complicações , Doença da Arranhadura de Gato/diagnóstico
19.
Arch Soc Esp Oftalmol ; 81(12): 717-9, 2006 Dec.
Artigo em Espanhol | MEDLINE | ID: mdl-17199167

RESUMO

CASE REPORT: A 58-year-old woman presented with 0.1 visual acuity in the left eye associated with a serous retinal detachment of the macula as the only ocular manifestation of cat scratch disease. This diagnosis was made by serum antibody titers and the clinical course. DISCUSSION: Although uncommon, cat scratch disease should be considered in patients with a serous detachment in the macula region of the retina.


Assuntos
Doença da Arranhadura de Gato/complicações , Descolamento Retiniano/etiologia , Animais , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Bartonella henselae/imunologia , Doença da Arranhadura de Gato/diagnóstico , Gatos , Eritema Nodoso/etiologia , Feminino , Humanos , Imunoglobulina M/sangue , Imunoglobulina M/imunologia , Lacerações/complicações , Pessoa de Meia-Idade
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